The CREBP research team works on big, neglected problems in health care. Our current research projects focus on four such neglected problems (Figure below), but these are supported by our work on the development of methods, tools, im-plementation, and capacity. These themes are each supported by NHMRC Centres for Research Excellence ($2.4M each over 5 years), and for overdiagnosis, a program grant ($10M shared with University of Sydney and Monash).

1. Antibiotic resistance: which currently leads to over 25,000 avoidable deaths per year in both Europe and the USA, threatening elective surgery, and a resurgence of the bacterial diseases of the 19th century.
2. Overdiagnosis: which has led to massive increase in the apparent prevalence of many diseases through definition change and overdetection, and is the largest contributor to the rise in health care costs.
3. Neglected non-pharmaceutical treatments: which are often as effective or more effective than their pharmaceutical cousins, but are poorly described, poorly “marketed”, and little used.
4. Waste in Medical Research: which we have estimated as over $100Billion per year resulting from avoidable design flaws, non-publication and poor reporting.
To support the work in these four neglected problems, we also work on the development of research infrastructure (people, methods, and software). The main areas are:
A. Automated systematic reviews, to support more rapid literature reviews in these areas. We currently use state-of-the-art tools, are developing & evaluating new software, and training staff, students and collaborators in these better methods.
B. Shared decision making at both clinical and public policy levels. Shared decision making—both generic methods and specific tools—lead to more appropriate decisions, and reduce health care usage in some areas. We are developing new methods, training, and tools to aid shared decisions and reduce overdiagnosis and antibiotic usage. For public policy, we have piloted “community juries” for prostate cancer screening.
C. Implementation and translation of research into practice, both locally and nationally. In all of the 4 themes, awe actively pursue research uptake, such as antibiotic stewardship programs, and run an annual 3-day workshop in research translation.